Biomarkers indicate a biological state and here, several findings on event-related potentials are summarised (potentials and connectivity in schizophrenia, ADHD, obsessive-compulsive disorder, etc.). Evoked components and oscillatory changes map to cognitive constructs, and therefore task induced oscillatory changes could be a new frontier in objective markers for cognitive disorders. With simple tasks, if well-specified for our hypotheses, we may benefit from M/EEG temporal resolution for this aim.

In this video, different topics cover some clinical aspects of MEG applications. First, examples of MEG neurodevelopmental studies are presented, along with challenges and practical considerations when working with children and MEG. Then, evoked responses to make sensory thresholds, also in children, is addressed, followed by connectivity studies in ADHD and dyslexia. The last examples are on pre-surgical localisation of epileptiform activity, as one of the broadest areas of MEG clinical applications.

From theory to behaviour, these studies try to break down the steps of perceptual decision making through MEG analysis. The results presented are from several recent studies on consciousness from a clinical point of view, studying the potential dissociation between perceptual decision and subjective reports. Regarding perceptual decision vs. conscious perception, non-equivalence, correlation and properties problems are addressed.

This video goes through several clinical experiments showing MEG possibilities. For example, non-temporal epilepsy is well covered, given that is one of the most common clinical applications of MEG, which has proved to be worth-considering in the presurgical evaluation of different patients (negative EEG and high suspicion of epilepsy, negative MRI, patients with discordant clinical findings, etc.). Soon enough, clinical applications will also emerge from MEG resting state functional connectivity investigations.